Fig. 2. Effects of acyclovir on skin lesions (A , B ), allodynia (C , D ), and hyperalgesia (E , F ) after herpesvirus inoculation. Mice were given herpes simplex virus type 1 inoculation on the unilateral hind paw on day 0, with the contralateral hind paw untreated, and acyclovir (10 mg/kg, five times a day) from day 5 to day 11 after inoculation. When mice showed either allodynia or hyperalgesia on day 20 after inoculation, they were considered to have postherpetic pain, and 23 mice were classified into two groups, non–postherpetic pain (A , C , E ; n = 11) and postherpetic pain (B , D , F ; n = 12). (A , B ) Lesion scores represented by diamonds and triangles were calculated on the basis of different lesion criteria (see Materials and Methods). The data given are mean and standard error of the mean. Hatched columns and dotted lines indicate the period of acyclovir administration.