![Fig. 1. Coughing response (open circles) versus anesthetic dose (expressed as a fraction of minimum alveolar concentration [MAC]). Using a Hill coefficient of 18.8 (estimated from the data of Neelakanta and Miller 10), the data of Klock et al. 1(6% of patients coughed while inhaling 1 MAC sevoflurane [thick line] compared with 25% of patients inhaling 1 MAC desflurane [thin line]) can be fit to a sigmoid curve. The resulting values for ED50(closed circles) differ by only 8%, smaller than the 11% bias in anesthetic concentrations used by Klock et al.](https://asa2.silverchair-cdn.com/asa2/content_public/journal/anesthesiology/96/5/10.1097_00000542-200205000-00040/2/40ff1.png?Expires=1716955798&Signature=MQsfsS1HTJfANsHTVWSe2yOkmdr-tiwJ-o9l8z2f9XzuCPi5Obxawf~jGGdry29PqnlkvSl52kdkSANdbpN81l9NiR9KA0CEFaTJ2Du~7HLFJdZcHJQJdfL~LBn5urnj8Ak7ULk7Y7-XL5DS8xj6xX5OOwxIrxqfU5TCJ8EasTzR3zA61gDpVIOuR3zV3hU5Id0NcVvprPnQpHs7VJaPSFSSlwAlO9Dail3aBg1zReA-~S8BHjOFsf7rhN-1U0Hkl1OPZsRilBAMqQc2~GyofHeXaZzNYcTHo1cB5nH59dxATuU6SyeuSbumfr3eW6NVSG19U2iI-OUqRqHPUcoIjA__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Fig. 1. Coughing response (open circles) versus anesthetic dose (expressed as a fraction of minimum alveolar concentration [MAC]). Using a Hill coefficient of 18.8 (estimated from the data of Neelakanta and Miller 10), the data of Klock et al. 1(6% of patients coughed while inhaling 1 MAC sevoflurane [thick line] compared with 25% of patients inhaling 1 MAC desflurane [thin line]) can be fit to a sigmoid curve. The resulting values for ED50(closed circles) differ by only 8%, smaller than the 11% bias in anesthetic concentrations used by Klock et al.
