Fig. 2. Individual data from group I (plasma compartment-controlled target-controlled infusion [TCI] at C^T= 5.4 μg/ml, Marsh model). 24Visual comparison of the time course of drug effect. Graphed is the moment of loss of consciousness (LOC), the propofol plasma concentration, bispectral index, and mean arterial pressures over time for all subjects. (Individual curve variability for predicted plasma propofol concentration calculated from the Marsh pharmacokinetics [Cp^CALC] is found to be caused by variability in anthropometric data, limited maximum infusion rate of the syringe pump, and time interval of 10 s for data acquisition.)