Fig. 1. (A ) Tracing curves of midazolam on collagen (2 μg/ml)-induced aggregation and (B ) concentration-inhibition curve of midazolam on collagen (2 μg/ml, circles)-, arachidonic acid (100 μm, triangles)-, and thrombin (0.5 U/ml, squares)-induced platelet aggregation in washed human platelet suspensions. Platelets were preincubated with midazolam (6–26 μm), and agonists were then added to trigger aggregation (lower tracings) and adenosine triphosphate release (upper tracings) (A ). Data are presented as a percentage of the control (mean ± SD, n = 5).