Fig. 3. Effects of intrathecal NMDA receptor antagonists pretreatment and posttreatment on secondary tactile allodynia observed after mild thermal injury. Graph plots are described in figure 2. Time courses of injured paw withdrawal threshold with intrathecal (IT) MK-801 (A ) and AP5 (B ) pretreatment (n = 6 in each group) and MK-801 (C ) and AP5 (D ) posttreatment (n = 6 in each group). *P < 0.05 versus  preinjury threshold by Friedman and modified Dunnett tests.