Fig. 1. (A ) Percent increase of left lung pulmonary vascular resistance (LPVR) in response to left mainstem bronchus occlusion (LMBO) in mice challenged with intraperitoneal saline solution (LPS−) or endotoxin (LPS+) 22 h earlier. Some mice in both groups further received intraperitoneal saline, N -acetylcysteine (NAC), or EUK-8 1 h after challenge (see table 1for experimental groups). *P < 0.001 versus saline-challenged mice; #P < 0.05 versus endotoxin-challenged mice; ##P < 0.05 versus saline-challenged mice treated with N -acetylcysteine; δP < 0.01 versus endotoxin-challenged mice; δδP < 0.05 versus saline-challenged mice treated with EUK-8. (B ) Percent increase of LPVR in response to LMBO in mice challenged with intraperitoneal saline (LPS−) or endotoxin (LPS+) 22 h earlier. Some mice in both groups further received intratracheal aerosolized saline, N -acetylcysteine, or EUK-8 1 h after challenge (see table 1for experimental groups). *P < 0.001 versus saline-challenged mice; #P < 0.05 versus endotoxin-challenged mice; ##P < 0.05 versus saline-challenged mice treated with N -acetylcysteine; δP < 0.05 versus endotoxin-challenged mice; δδP < 0.05 versus saline-challenged mice treated with EUK-8.