Fig. 2. Effects of intrathecal administration of ONO-8711 (1, 10, and 100 μg) and saline on withdrawal threshold to mechanical stimulation on ipsilateral (A  and B ) and contralateral (C  and D ) sides of the hind paw 3 h (early phase;A  and C ) and 15 h (late phase;B  and D ) after carrageenan injection. Data are expressed as medians (horizontal lines) with first and third quartiles (boxes) and 10th and 90th percentiles (vertical lines). N = 6 in each group. *P < 0.05 compared with inflammation, †P < 0.05 among the four doses.