Fig. 1. (A ) Time course of analgesia (measured by the response to a deep forceps pinch of the fifth metatarsal) after injection of 0.5% plain lidocaine (open circles) or 0.5% lidocaine with epinephrine (1:100,000; filled circles). n = 10 at each time point. (B ) Time course of percent animals completely blocked (measured by response to deep pinch of fifth metatarsal) after injection of 0.5% plain lidocaine (open circles) or 0.5% lidocaine with epinephrine (1:100,000; filled circles). n = 10 at each time point.