Table 2. Parameter Estimates^*of Three-compartment Pharmacokinetic Model for Rapacuronium (Model No. 11)

* Standard error and interindividual variation are reported only for those parameters estimated by NONMEM. For those structural parameters with more than one component (i.e.,  Fraction absorbed with k  ^absorption(1) and Cl), interindividual variability applies to the combination of components.

† Computed as

where Ω²= variance (η); sixty-eight % of the population lies within this range of the typical value.

‡ The value 0.0736 applies to the value 0.276; the value 0.0236 applies to the value 0.0918.

§ The value 0.966 applies to the value 4.77; the value 5.17 applies to the value 8.57.

∥ Although the standard error of Cl^rapidand the non–weight-normalized component of Cl are large (suggesting that these values do not differ from zero), a likelihood profile shows justification for both the three-compartment model and the two components of Cl.

# Not determined because interindividual variability was not justified statistically for this parameter.

k  ^absorption(1) = rate constant for absorption from the first absorption compartment;k  ^absorption(2) = rate constant for absorption from the second absorption compartment.