Fig. 5. (A ) Effect of indomethacin on etomidate-induced attenuation of the pulmonary vasorelaxant response to lemakalim in endothelium-intact (E+) rings. Indomethacin pretreatment abolished the etomidate-induced attenuation of lemakalim vasorelaxation. (B ) Effect of indomethacin on ketamine-induced attenuation of the pulmonary vasorelaxant response to lemakalim in endothelium-intact (E+) rings. The ketamine-induced attenuation (IC50:*P < 0.05; Rmax:#P < 0.05) of lemakalim vasorelaxation was still observed in indomethacin-pretreated rings.