Fig. 1. Effect of inhibitors on Ca2+release induced by cADPR. Experiments were carried as described in Materials and Methods. Values are mean ± SD. The Ca2+release induced by 10 μm cADPR was tested in microsomes pretreated with either no addition (control), 30 μm ruthenium red (RR), 1 mg/ml heparin (Heparin), or 10 μm 8-Br-cADPR (a specific cADPR antagonist).

Fig. 1. Effect of inhibitors on Ca2+release induced by cADPR. Experiments were carried as described in Materials and Methods. Values are mean ± SD. The Ca2+release induced by 10 μm cADPR was tested in microsomes pretreated with either no addition (control), 30 μm ruthenium red (RR), 1 mg/ml heparin (Heparin), or 10 μm 8-Br-cADPR (a specific cADPR antagonist).

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