Table 1. Plasma and Urine Pharmacokinetic Parameters after the First, Second, and Third Aerosol (n = 9)

Values were not significantly different (one-way analysis of variance for AUC^{S 0→24 h}and C^max; Kruskal–Wallis for C^minand A^{U 0→24 h}). All data are expressed as mean ± SD.

A^{U 0→24 h}= amount of drug excreted in the urine in the 24-h period; AUC^{S 0→24 h}= area under the plasma concentration–time curve; C^max= peak plasma concentration; C^min= trough plasma concentration.