Fig. 1. Plasma concentrations of amikacin (AMK; mean ± SD) following three consecutive aerosols (40 mg · kg−1· d−1) in nine piglets ventilated during 4 days. Following each aerosol (black arrows), amikacin plasma concentrations significantly decreased (P < 0.0001, two-way analysis of variance) in similar proportion (no interaction). Peak plasma and trough amikacin concentrations were not significantly different following the first, second, and third aerosol, suggesting a lack of systemic accumulation.
