Fig. 5. Time-dependent effect of halothane on interleukin-6 (IL-6), macrophage inflammatory protein-2 (MIP-2), monocyte chemoattractant protein-1 (MCP-1), and protein secretions by recombinant murine interleukin-1β (rmIL-1β)-stimulated alveolar type II cells. rmIL-1β-stimulated rat alveolar type II cells were exposed either to air or halothane (1 minimum alveolar concentration [MAC]) during 1, 2, 3, and 4 h. Cytokine concentrations were then measured in cell supernatants. Results are expressed as the percentage of values obtained for air-exposed cells, mean ± SD; †P < 0.05 and ‡P < 0.001 versus air.