Fig. 5. Effects of wortmannin on pinacidil activated adenosine triphosphate–sensitive potassium current (IKATP) at 0.5 mm internal ATP. The voltage protocol was as described in figures 1 and 2. Wortmannin (100 μm) was applied intracellularly via the recording pipette. Wortmannin did not significantly affect IKATPactivated by pinacidil alone (P = 0.139; n = 6) but prevented the sensitization effect of isoflurane (*P < 0.05, isoflurane + pinacidil vs. pinacidil alone, n = 8; **P < 0.05, isoflurane + pinacidil + wortmannin vs. isoflurane + pinacidil, n = 7).