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Fig. 6. The percentages of whole cell Ca2+current (ICa) sensitive to the L-type Ca2+channel blocker nifedipine (Nifed, 10 μm), the N-type Ca2+channel blocker ω-conotoxin GVIA (GVIA, 1 μm), and the percentage that was resistant to a combination of both. CAP (+) = capsaicin responsive; CAP (−) = capsaicin unresponsive; Fent (+) = fentanyl sensitive; Fent (−) = fentanyl insensitive. The CAP-unresponsive, fentanyl-insensitive cells (n = 3) had significantly less L- and N-type ICaand a greater percentage of ICathat was resistant to both blockers (*P < 0.01 vs. CAP-sensitive, fentanyl-sensitive cells, n = 4; †P < 0.001 vs. CAP-sensitive, fentanyl-insensitive cells, n = 6).

Fig. 6. The percentages of whole cell Ca²⁺current (I^Ca) sensitive to the L-type Ca²⁺channel blocker nifedipine (Nifed, 10 μm), the N-type Ca²⁺channel blocker ω-conotoxin GVIA (GVIA, 1 μm), and the percentage that was resistant to a combination of both. CAP (+) = capsaicin responsive; CAP (−) = capsaicin unresponsive; Fent (+) = fentanyl sensitive; Fent (−) = fentanyl insensitive. The CAP-unresponsive, fentanyl-insensitive cells (n = 3) had significantly less L- and N-type I^Caand a greater percentage of I^Cathat was resistant to both blockers (*P < 0.01 vs. CAP-sensitive, fentanyl-sensitive cells, n = 4; †P < 0.001 vs. CAP-sensitive, fentanyl-insensitive cells, n = 6).

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