Fig. 1. Effect of isoflurane on the sarcolemmal KATPchannel activated by 2,4-dinitrophenol (DNP). Channel activity was monitored in the cell-attached patch mode at a membrane potential of −46 mV. The pipette and bath solution contained 5 mm K. Single channel traces and corresponding amplitude histograms are shown in DNP, DNP + isoflurane, and DNP + isoflurane + glibenclamide. The times shown in the brackets denote the period at which channel activity was recorded. The arrow indicates zero current level.