Fig. 3. The kinetic effect of isoflurane on 2,4-dinitrophenol (DNP)-activated KATPchannel. Cumulative channel open probability is plotted against time for the DNP group (▴, n = 6) and the DNP + isoflurane group (○, n = 8). For the DNP + isoflurane group, isoflurane was added during the 6-min mark and washed out at the 10-min mark, as denoted on the plot. *P < 0.01 versus DNP group; #P < 0.01 versus 0 min of isoflurane + DNP group.