Fig. 5. Effect of isoflurane on the K^ATPchannel activated by adenosine diphosphate (ADP). (Top ) Single-channel current traces monitored in the inside-out patch mode in control, ADP, ADP + isoflurane. Control condition was obtained in 0.5 mm ATP. ADP (0.1 mm) and isoflurane (0.5 mm) were added to the internal (bath) solution. The arrows indicate zero current level. (Bottom ) Summarized data from 10 patches. *P < 0.05 versus  control group.