Fig. 9. Effect of protein kinase C (PKC) activation and isoflurane on the KATPchannel in excised patches. A summary of the effect of isoflurane on the KATPchannel activated by 12,13-dibutyrate (PDBu; 0.5 μm) is shown. The control condition was obtained in 500 μm adenosine triphosphate. Open probability was determined from channel recordings obtained from inside-out patches (n = 6). *P < 0.05 versus control.