Fig. 4. Histograms depicting the slope (Ees;top ) of the left atrial (LA) end-systolic pressure–volume relation, LA relaxation (RLA;middle ), and the slope (Eer;bottom ) of the LA end-reservoir pressure–volume relation (dynamic chamber stiffness) under baseline conditions (CON) and during the administration of 0.6, 0.9, and 1.2 MAC desflurane (solid bars), sevoflurane (open bars), or isoflurane (hatched bars). Data are mean ± SEM from eight experiments conducted in acutely instrumented dogs in each group. *Significantly (P < 0.05) different from CON; †significantly (P < 0.05) different from 0.6 MAC. Reprinted with permission. 33