Table 2. Pharmacokinetic Parameters after Intravenous Infusion of γ-Hydroxybutyric Acid in Hypovolemic and Control Groups

Results are expressed as mean ± SD.

*P < 0.05, Mann–Whitney U test.

GHB =γ-hydroxybutyric acid (390 mg · kg⁻¹· 5 min⁻¹); V^max= theoretical maximum rate of the elimination; K^M= Michaelis–Menten constant; V^C= volume of distribution of the central compartment; V^T= volume of distribution of the peripheral compartment; V^SS= total volume at steady-state; Cl^d= intercompartmental clearance; AUC^0–420= area under the curve extrapolated from time 0 to 420 min.