Table 5. Pain Score, Patient-controlled Analgesia Bolus Dose, and Drug Consumption in the ′Good′ Combinations of the Final Complex

For each combination, morphine concentration in patient-controlled analgesia solution (mg/ml), ketamine concentration in patient-controlled analgesia solution (mg/ml) and lockout interval (min) are given in brackets. The pain score of each combination was calculated by computing the mean for each patient, using all observations on pain at rest and during mobilization and calculating the average pain score from the individual means of all patients. Data for pain score are presented as mean (SD) since the ranking was done using mean values (see  Appendix). Patient-controlled analgesia bolus dose represents the median (range) of the drug dose reached after adjusting the bolus delivered in individual patients according to analgesia and side effects. Drug consumption (median and ranges) was calculated by dividing the total consumption by the duration of the study period.