Fig. 5. The effect site unit disposition functions (i.e. , response to a 1-mg bolus dose) obtained from the pharmacokinetic (PK)–pharmacodynamic (PD) parameters of Schnider et al.  12,13(solid line ), the pharmacokinetic parameters of Marsh et al.  10and the k^e0of Schnider et al.  (dotted line ), and the pharmacokinetic parameters of Marsh et al.  and the k^e0obtained from the t^peakof Schnider et al.  (dashed line ).