Fig. 3. The spinal nerve ligation of neuropathic pain model caused significant mechanical allodynia (low thresholds for von Frey filament stimulation) (A ) and cold allodynia (responses to acetone) (B ) in the ipsilateral paw. Time course of the effects of intrathecal radolmidine 2.5 μg (filled circles), intrathecal dexmedetomidine 2.5 μg (open squares), and intrathecal saline 10 μl (open circles) are shown. The mean (SEM) von Frey filament force that induced paw withdrawal (A ) and the mean number of withdrawals to five consecutive acetone stimuli (B ) are shown. The respective dose–response curves are shown (C  and D ).The dotted lines indicate the baseline values.