Fig. 4. The effects of radolmidine and dexmedetomidine on spontaneous locomotion. As an example of the decrease in locomotion, the mean (SEM) number of activity counts in the motility box after intrathecal administration of radolmidine 5 μg (filled circles), dexmedetomidine 5 μg (open squares), or saline 10 μl (open circles) is shown (A ). The dose–response curves for radolmidine (filled circles) and dexmedetomidine (open squares) plotting mean percentage of inhibition of activity, as compared with the locomotor activity in the saline control group (SEM) 0–15 min after intrathecal administration of the drugs, are shown (B ). The asterisks indicate statistically significant difference between the drugs.