Fig. 4. Time course effects of force of contraction of isolated human right atrial trabeculae during a 30-min hypoxic challenge followed by 60 min of reoxygenation (control; •). A 15-min exposure to sevoflurane 2% alone (▴) or in the presence of 5-HD (⋄), HMR 1098 (▵), and DPX (▿) was followed by a 7-min washout period before the 30-min hypoxic challenge. 5-HD = 5 hydroxydecanoate; DPX = 8-cyclopentyl-1,3-dipropylxanthine. Data are mean ± SD. *P < 0.05 vs.  baseline value; #P < 0.05 vs.  baseline value for all groups; §P < 0.05 vs.  baseline value and PC for control, sevoflurane + 5-HD, sevoflurane + HMR 1098, and sevoflurane + DPX groups; +P < 0.05 vs.  baseline, control, PC, sevoflurane + 5-HD, and sevoflurane + DPX; ×P < 0.05 vs.  baseline, control, PC, and sevoflurane + DPX.

Fig. 4. Time course effects of force of contraction of isolated human right atrial trabeculae during a 30-min hypoxic challenge followed by 60 min of reoxygenation (control; •). A 15-min exposure to sevoflurane 2% alone (▴) or in the presence of 5-HD (⋄), HMR 1098 (▵), and DPX (▿) was followed by a 7-min washout period before the 30-min hypoxic challenge. 5-HD = 5 hydroxydecanoate; DPX = 8-cyclopentyl-1,3-dipropylxanthine. Data are mean ± SD. *P < 0.05 vs.  baseline value; #P < 0.05 vs.  baseline value for all groups; §P < 0.05 vs.  baseline value and PC for control, sevoflurane + 5-HD, sevoflurane + HMR 1098, and sevoflurane + DPX groups; +P < 0.05 vs.  baseline, control, PC, sevoflurane + 5-HD, and sevoflurane + DPX; ×P < 0.05 vs.  baseline, control, PC, and sevoflurane + DPX.

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