Fig. 4. Propofol curtailed the oxygen–glucose deprivation (OGD)–induced decrease of the glutamate uptake rate. Uptake experiments were performed at the end of the injury, before reoxygenation. A 90-min OGD elicited a 40.6 ± 13.3% impairment of the glutamate uptake compared to the transport activity measured in sham wash (SW) cells. Propofol counteracted, in a dose-dependent manner, this decrease of the glutamate uptake rate. Moreover, 10 μm propofol maintained the glutamate uptake rate at the level measured in sham wash cells. *P < 0.05 versus control. n = 6 cultures per condition pooled from three experiments.