Fig. 2. Isoflurane (ISO) pretreatment results in prolonged potentiation of sarcolemmal adenosine triphosphate–sensitive potassium channel current (IKATP). (  A ) Representative time course experiment in which a voltage clamped myocyte was subjected to 10 min of pretreatment with 0.5 mm isoflurane and 10 min of anesthetic washout before application of 5 μm pinacidil (PIN). After isoflurane pretreatment and its washout, the pinacidil-elicited IKATPwas greater compared with that in anesthetic-free control (  fig. 1A). This suggested that the channel remains sensitized to opening even after withdrawal of the anesthetic. (  B ) Time course of IKATPwith 30 min of washout after 10 min of isoflurane exposure. Magnitude of pinacidil-activated IKATPwas still greater than in anesthetic-free control. GLIB = glibenclamide. 

Fig. 2. Isoflurane (ISO) pretreatment results in prolonged potentiation of sarcolemmal adenosine triphosphate–sensitive potassium channel current (IKATP). (  A ) Representative time course experiment in which a voltage clamped myocyte was subjected to 10 min of pretreatment with 0.5 mm isoflurane and 10 min of anesthetic washout before application of 5 μm pinacidil (PIN). After isoflurane pretreatment and its washout, the pinacidil-elicited IKATPwas greater compared with that in anesthetic-free control (  fig. 1A ). This suggested that the channel remains sensitized to opening even after withdrawal of the anesthetic. (  B ) Time course of IKATPwith 30 min of washout after 10 min of isoflurane exposure. Magnitude of pinacidil-activated IKATPwas still greater than in anesthetic-free control. GLIB = glibenclamide. 

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