Fig. 6. Protein kinase C (PKC)-δ and PKC-ϵ activation sensitizes the sarcolemmal adenosine triphosphate–sensitive potassium channel and mimics isoflurane effects. Peptide activators of specific PKC isoforms were applied in the external solution before myocyte exposure to pinacidil (PIN). Shown are representative time courses. ( A ) After treatment with activator of PKC-δ, pinacidil-elicited sarcolemmal adenosine triphosphate–sensitive potassium channel current (IKATP) was enhanced to the same extent as after isoflurane exposure. ( B ) Exposure to specific activator of PKC-ϵ also sensitized sarcolemmal adenosine triphosphate–sensitive potassium channel to pinacidil. GLIB = glibenclamide.