Fig. 5. Effects of combining bisindolylmaleimide I (Bis I; 10−6m), Y 27632 (Y; 5 × 10−7m), and PD 098059 (PD; 10−5m) on the ropivacaine (Rop)–induced, dose-dependent, cumulative contraction of rat aortic smooth muscle. Endothelium-denuded rings were randomly pretreated with one of the four combinations for 15 min and then challenged by ropivacaine in a cumulative dose manner. The tension was measured using isometric force transducers and was expressed as a percent of the 30 mm potassium chloride–induced contraction. * P < 0.05, ** P < 0.01 versus control (n = 6).
