Fig. 3. Arterial blood inulin concentration histories for the first 2.0 min (illustrating the first- and second-pass peaks) and to the limit of detection (inset ) after right atrial injection in one dog when it was awake (closed symbols) and when it was anesthetized with 3.5% isoflurane (open symbols). The symbols represent measured inulin concentrations, and the lines represent concentrations predicted by the models.