Table 3. Pharmacokinetic Parameters for Recirculatory Inulin Pharmacokinetics

Data are mean (SD).

* The volumes (V) of the central (c), rapidly equilibrating (fast) nondistributive (nd-f), and slowly equilibrating nondistributive (nd-s) circuits and the rapidly equilibrating (fast) (t-f) and slowly equilibrating (t-s) tissues, and the volume of distribution at steady-state (V^ss), which equals the sum of all volumes.

† The clearances (Cl) of the rapidly equilibrating (fast) nondistributive (nd-f) and slowly equilibrating nondistributive (nd-s) circuits and the rapidly equilibrating (fast) (t-f) and slowly equilibrating (t-s) tissues, elimination clearance (e), and the sum of all clearances (ΣCl), which equals the ICG (dye dilution) cardiac output determined at the moment of marker injection.

‡ Correlated with end-tidal isoflurane concentration (P < 0.05), as determined by Spearman rank-order correlation.

§ Correlated with cardiac output (P < 0.05), as determined by least-squares linear regression.

∥ Different from Awake control (P < 0.05), as determined by Scheffe multiple comparison test.

# Different from 1.7% isoflurane (P < 0.05), as determined by Scheffe multiple comparison test.

** Different from 2.6% isoflurane (P < 0.05), as determined by Scheffe multiple comparison test.