Fig. 3. Electroencephalographic characteristics of seizures induced by bupivacaine in wild-type and TASK knockout mice. Mice were fitted with electrodes for measuring cortical electroencephalogram (EEG) and injected with bupivacaine (3.75, 5, and 6.25 mg/kg, intravenously). Representative EEG recordings from a wild-type and a TASK^−/−mice are depicted, under control conditions, during a seizure induced by 3.75 mg/kg intravenous bupivacaine, and then after recovery (inset ). A fast Fourier transform of the EEG data reveals a large increase in power at ⩽ 5 Hz specifically during the bupivacaine-induced seizure.