Fig. 6.  Accumulation of ceramides and hydroxy-acylcarnitine species and depletion of acetylcarnitine after perfusion with propofol or Intralipid. (A ) Propofol significantly increased ceramide levels compared with control and Intralipid hearts. (B ) Both Intralipid and propofol significantly decreased acetylcarnitine levels compared with control. (C ) Both Intralipid and propofol increased hydroxy-acylcarnitines (OH-acylcarnitines) levels compared with control hearts. CTL = control group with time-matched perfusion (n = 5); PROP100 = 100 μm propofol (n = 8); INTRA100 = corresponding Intralipid control (n = 7).