Fig. 3. Concentration-response curve of resting and inactivated block of wild-type Nav1.7 Na+channels by duloxetine. Relative potency of duloxetine of the resting and inactivated Na+channels in neuronal hNav1.7 isoform (• and ○, respectively) was compared. Data were taken from experiments at various drug concentrations with pulse protocols described in Fig. 2. Data were then fitted with a Hill equation, y = 1/[1 + (x /IC50)n H]; values of the IC50(50% inhibitory concentration) and the Hill coefficient (n H) are listed in table 1. h = human.