Fig. 3.
Effect of xenon and argon on secondary injury development. (A) Xenon is particularly effective at preventing development of secondary injury. At the 24, 48, and 72 h time points, xenon-treated slices (red bar) were not significantly different to uninjured sham slices (white bar). At the 72-h time point, secondary injury in xenon-treated slices was 50 ± 5% of secondary injury in untreated injured slices (black bar). The error bars are standard errors. (B) Argon attenuates development of secondary injury at 24, 48, and 72 h after injury. At the 72-h time point, argon-treated slices (cyan bar) were 66 ± 8% of secondary injury in untreated injured slices (black bar). The error bars are standard errors. *Indicates value significantly different (P < 0.001) from control injury at each time point. #Indicates value significantly different (P < 0.01) from control injury (N = 141 control traumatic injury; N = 105 sham; N = 104 xenon; N = 44 argon).