Fig. 7.
Coadministration of A85380 alleviates remifentanil-induced respiratory depression in adult rats. (A and B) Representative whole-body plethysmographic recordings from two adult rats. A bolus of remifentanil (5 μg/kg IV bolus over 20 s, coadministrated with saline) caused marked apneas and decreased minute ventilation (VE) in the first minute (A). Coadministration of A85380 (0.06 mg/kg, IV) with remifentanil markedly reduced the remifentanil-induced apneas and decrease in VE (B). (C–E) Population data (mean and SD). *P < 0.05, ***P < 0.001, statistically significant difference in compared groups, using one-way ANOVA (Holm–Sidak method). n = 8 animals each group.

Coadministration of A85380 alleviates remifentanil-induced respiratory depression in adult rats. (A and B) Representative whole-body plethysmographic recordings from two adult rats. A bolus of remifentanil (5 μg/kg IV bolus over 20 s, coadministrated with saline) caused marked apneas and decreased minute ventilation (VE) in the first minute (A). Coadministration of A85380 (0.06 mg/kg, IV) with remifentanil markedly reduced the remifentanil-induced apneas and decrease in VE (B). (C–E) Population data (mean and SD). *P < 0.05, ***P < 0.001, statistically significant difference in compared groups, using one-way ANOVA (Holm–Sidak method). n = 8 animals each group.

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