Box and whisker plots showing base coverage for the RYR1 and CACNA1S genes for a cohort of 870 probands. The bottom and top lines of the box represent the 1st and 3rd quartile, respectively; the midline represents the median value. The bottom and top whiskers represent the lowest and highest values within 1.5 times the interquartile range. Outliers have been excluded. Values on the y-axis are represented as fraction of total coding exonic bases for each gene.