Fig. 2.
CX546 relieves mechanical and cold allodynia in spared nerve injury (SNI)-treated animals in a dose-dependent manner. (A) SNI-treated animals after intraperitoneal administration of CX546 demonstrated reduced mechanical allodynia compared to dimethyl sulfoxide (DMSO) control at doses of 10 mg/kg and 5 mg/kg, but not at 2.5 mg/kg. ***P < 0.001, two-way ANOVA with post hoc Bonferroni multiple comparison tests. DMSO group, n = 9. CX546 group, n = 11. (B) SNI-treated animals after intraperitoneal administration of CX546 demonstrated reduced cold allodynia compared to DMSO control at doses of 10 mg/kg and 5 mg/kg, but not at 2.5 mg/kg. **P < 0.01, *P < 0.05, two-way ANOVA with post hoc Bonferroni multiple comparison tests. DMSO group, n = 9. CX546 group, n = 11. Error bars represent SEM.

CX546 relieves mechanical and cold allodynia in spared nerve injury (SNI)-treated animals in a dose-dependent manner. (A) SNI-treated animals after intraperitoneal administration of CX546 demonstrated reduced mechanical allodynia compared to dimethyl sulfoxide (DMSO) control at doses of 10 mg/kg and 5 mg/kg, but not at 2.5 mg/kg. ***P < 0.001, two-way ANOVA with post hoc Bonferroni multiple comparison tests. DMSO group, n = 9. CX546 group, n = 11. (B) SNI-treated animals after intraperitoneal administration of CX546 demonstrated reduced cold allodynia compared to DMSO control at doses of 10 mg/kg and 5 mg/kg, but not at 2.5 mg/kg. **P < 0.01, *P < 0.05, two-way ANOVA with post hoc Bonferroni multiple comparison tests. DMSO group, n = 9. CX546 group, n = 11. Error bars represent SEM.

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