Fig. 7.
Intraperitoneal administration of CX516 in spared nerve injury (SNI)-treated animals relieves mechanical and cold allodynia. (A) Intraperitoneal administration of CX516 in SNI-treated animals decreases their mechanical allodynia in a dose-dependent manner. Mechanical allodynia was decreased at CX516 doses of 40 mg/kg and 20 mg/kg, but not at 10 mg/kg. ***P < 0.001, *P < 0.05, two-way ANOVA with post hoc Bonferroni multiple comparison tests. For 10 mg/kg, n = 7. For 20 mg/kg, n = 10. For 40mg/kg, n = 7. (B) Intraperitoneal administration of CX516 in SNI-treated animals decreases their cold allodynia in a dose-dependent manner. Cold allodynia was decreased at CX516 doses of 40 mg/kg, but not at 20 mg/kg or 10 mg/kg. *P < 0.05, two-way ANOVA with post hoc Bonferroni multiple comparison tests. For 10 mg/kg, n = 7. For 20 mg/kg, n = 10. For 40mg/kg, n = 7. Error bars represent SEM. DMSO = dimethyl sulfoxide.

Intraperitoneal administration of CX516 in spared nerve injury (SNI)-treated animals relieves mechanical and cold allodynia. (A) Intraperitoneal administration of CX516 in SNI-treated animals decreases their mechanical allodynia in a dose-dependent manner. Mechanical allodynia was decreased at CX516 doses of 40 mg/kg and 20 mg/kg, but not at 10 mg/kg. ***P < 0.001, *P < 0.05, two-way ANOVA with post hoc Bonferroni multiple comparison tests. For 10 mg/kg, n = 7. For 20 mg/kg, n = 10. For 40mg/kg, n = 7. (B) Intraperitoneal administration of CX516 in SNI-treated animals decreases their cold allodynia in a dose-dependent manner. Cold allodynia was decreased at CX516 doses of 40 mg/kg, but not at 20 mg/kg or 10 mg/kg. *P < 0.05, two-way ANOVA with post hoc Bonferroni multiple comparison tests. For 10 mg/kg, n = 7. For 20 mg/kg, n = 10. For 40mg/kg, n = 7. Error bars represent SEM. DMSO = dimethyl sulfoxide.

Close Modal
This Feature Is Available To Subscribers Only

or Create an Account

Close Modal
Close Modal