Effects of continuous administration of SS-31 during chronic oxaliplatin administration on cold hypersensitivity and mechanical allodynia. SS-31 at 5 mg kg⁻¹ day⁻¹ or vehicle was continuously administered while mice were given three weekly administrations of oxaliplatin (each dose at 15 mg/kg). Tests were performed 4 days after each oxaliplatin injection to assess cold hypersensitivity and mechanical allodynia.(A) Cold hypersensitivity was assessed by the 15°C-cold plate test (see text) (n = 6 for each group). (B) Mechanical allodynia was assessed by the von Frey hair test (n = 6 for each group). Data were given as the mean ± SEM and analyzed by two-way ANOVA for repeated measures (A, group effect: P < 0.001; time effect: P < 0.001; B, group effect: P = 0.029; time effect: P < 0.001) followed by Bonferroni multiple comparison tests. * P < 0.05 vs. corresponding time point of control group (B). OHP = oxaliplatin; VEH = vehicle.