Fig. 3.
Guarding pain score (GPS), paw withdrawal latency (PWL), and 50% mechanical withdrawal threshold (MT) after incision. (A) Time courses of GPSs after incision in α-calcitonin gene–related peptide (αCGRP) knockout mice and in wild-type (WT) mice. n = 12 in αCGRP knockout mice, n = 15 in WT mice. (B) Time courses of PWLs after incision in αCGRP knockout mice and WT mice. n = 6 in each group. (C) Time courses of MTs after incision in αCGRP knockout mice and WT mice. n = 6 in each group. GPSs were significantly increased at 2–6 h after incision, and PWLs and MTs were significantly decreased at 2–72 h after incision compared with those before incision in both αCGRP knockout mice and WT mice. There were no significant differences in GPSs, PWLs, and MTs between αCGRP knockout mice and WT mice at each time point. Data for GPS and PWL are expressed as means ± SDs. Data for MTs are expressed as medians (horizontal line) with 1st and 3rd quartiles (boxes) and 10th and 90th percentiles (vertical lines). *P < 0.05, versus 0 h (baseline).