Fig. 4.
Dog data superimposed on data from human patients receiving multiple infusion rates of the racemic mixture of esmolol (RS-esmolol). Human data were adapted from reference 24. Each circle represents data from a separate study. The size of each circle represents the weighting of each study and is a reflection of both the magnitude of the difference in mmHg and the number of patients in the study. For both dogs and humans, blood pressure was normal at baseline and subjects were anesthetized. Difference between human RS-esmolol and dog RS-esmolol is attributed to the difference in elimination half-life of esmolol of 9 min in humans and 4 min in dogs.