Hypnotic activities of cyclopropyl-methoxycarbonyl metomidate (CPMM) and etomidate. (A) CPMM and etomidate dose–response relations for loss of righting reflexes (LoRRs) after bolus administration. The curve is a fit of the CPMM data to a Hill equation with the maximum and minimum constrained to 0 (no LoRR) and 1 (LoRR), respectively, and provides an approximate ED50 value of 0.8 mg/kg. (B) Duration of LoRRs after bolus administration of either CPMM or etomidate. For both drugs, the duration of LoRR increased linearly with the logarithm of the dose. The respective X-intercept and slope of this relation was 0.88 mg/kg (95% CI, 0.50 to 1.27 mg/kg) and 9.9 (95% CI, 9.4 to 12.5) for CPMM and 0.37 mg/kg (95% CI, 0.18 to 0.52 mg/kg) and 24 (95% CI, 15 to 34) for etomidate. Each symbol represents data obtained from a single dog experiment.
