Fig. 5.
Pharmacokinetics of cyclopropyl-methoxycarbonyl metomidate (CPMM), etomidate and their respective primary metabolites. T = 0 is the time of hypnotic bolus administration (for single-bolus-only studies) or the end of the 2-h hypnotic infusion (for bolus followed by 2-h infusion studies). (A) Time-dependent change in plasma CPMM and metabolite concentrations after administering a single CPMM bolus (4 mg/kg). (B) Time-dependent change in plasma etomidate and metabolite concentrations after administering a single etomidate bolus (2 mg/kg). (C) Time-dependent change in plasma CPMM and metabolite concentrations after administering a single bolus followed by a 2-h continuous infusion of CPMM. (D) Time-dependent change in plasma etomidate and metabolite concentrations after administering a single bolus followed by a 2-h continuous infusion of etomidate. Each data point is the mean ± SD (n = 3 or 4 dogs for each data point).