Fig. 2.
Erythrocytes flux in intestinal villi in each group. *P < 0.0001 for control vs. sham group. *P = 0.0007, *P < 0.0001, *P < 0.0001 (FR50, FRNE50, FRNE60vs. control, respectively). P = 0.018 for FR60vs. control group. Control group and group receiving norepinephrine without fluid (NE) were represented with the average value of the group imputed for the missing measurement points due to animal death. Additional curves with dashed lines (i.e., control “0 value” and NE “0 value”) correspond to the values obtained for the group when a zero value was considered for the parameter when the animal was dead at the studied time (to be more conservative no statistical tests were made with this imputation). FR50 and FR60 = groups resuscitated with fluid without norepinephrine to target a mean arterial pressure (MAP) of 50 or 60 mmHg, respectively; FRNE50 and FRNE60 = groups resuscitated with fluid and NE to target a MAP of 50 or 60 mmHg, respectively; NE = group receiving norepinephrine without fluid; OBS = observation phase; T0 = baseline; T30 = end of the volume-controlled hemorrhage; T60 = during uncontrolled hemorrhagic shock; T90 = end of uncontrolled hemorrhagic shock; T210 = end of the observation phase; TRANS = transfusion; UHS = uncontrolled hemorrhagic shock; VCH = volume-controlled hemorrhage.