Simulation analysis using the final pharmacokinetic–pharmacodynamic model at different dosing regimens (1, 3, 5, and 10 ml/h of 0.2% ropivacaine for 48 h after a single-bolus dose of 100 mg). The shaded areas represent the 95% CIs of the model simulations (N = 1,000), and the solid black line depicts the median profile.