Cytokine-induced neutrophil chemokine (CINC)-1 blockade prevents transforming growth factor (TGF)-β1–mediated inhibition of the epinephrine-stimulated alveolar fluid clearance (AFC) in rats. Pretreatment with a blocking antibody to CINC-1 but with its isotype control antibody prevents TGF-β1–induced inhibition of the epinephrine- stimulated AFC in rats (AFC control 7.1% ± 1.3/30 min, epinephrine-treated 14.2% ± 1.3/30 min). Results are means ± interquartile range (n = 6 in each group); *P < 0.05 from controls. Cont = control; IgG = immunoglobulin G.