Fig. 3.
Benzbromarone (Benz) relaxes an established leukotriene D4 (LTD4)-induced contraction in human airway smooth muscle. Human airway smooth muscle was contracted with LTD4 (20 nM) and then treated with cumulatively increasing concentrations of Benz (10, 50, and 100 μM) or vehicle (0.1% dimethyl sulfoxide) at 30-min intervals. Treatment with 10, 50, and 100 μM Benz resulted in significant relaxation (*P < 0.05, **P < 0.01, and ***P < 0.001; n = 8 samples from four patients).